Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum 1st ed. 2016 Edition PDF ebook Free
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum 1st ed. 2016 Edition PDF Download
By Nina Dragicevic (Editor), Howard I. Maibach (Editor)
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
- Hardcover:411 pages
- Publisher:Springer; 1st ed. 2016 edition (November 6, 2015)
The main function of skin is the protection of the body from the external environment by preventing loss of water and the ingress of exogenous substances. This implies that the skin acts as a barrier for the diffusion of substances into the underlying tissue. Despite this role, the skin has become recognized as an important drug delivery route which can be reached directly. It is an ideal site for the application of drugs for achieving local (topical) and systemic (transdermal) drug effects. Local or topical drug delivery assumes treating various skin diseases, while transdermal delivery aims to achieve systemically active drug levels in order to treat systemic diseases. Drugs have been applied to the skin to achieve also regional drug delivery which involves drug application to the skin to treat or alleviate disease symptoms in deep tis- sues beneath the skin (such as in musculature, etc.). Topical and transdermal drug delivery offer a number of advantages compared to other conventional routes, and hence they are of great interest to pharmaceutical research, which explains the increasing interest in skin as a site of drug application. However, skin represents a formidable barrier for percutaneous drug absorption, being of crucial importance for achieving topical and transdermal effects of drugs. Signifi cant efforts have been devoted to developing strategies to overcome the impermeability of intact human skin. There are many ways for circumventing the stratum corneum, which provides the main barrier to drug penetration. These methods can be divided into chemical and physical penetration enhancement methods, i.e. percutaneous penetration enhancers, which are described in this book series Percutaneous Penetration Enhancers . The aim of this book series is to provide to readers working in academia and industry, including young researchers, an up-to-date comprehensive work describing all the important topics required to understand the principles of enhancing transdermal and dermal drug delivery. The book series contains fi ve books.